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ADMINISTRATION: bOPV must only be administered orally. Two drops are delivered directly into the mouth from the multidose vial by dropper or dispenser. Care should be taken not to contaminate a multidose dropper with saliva of the vaccinee.
Once opened, multi-dose vials should be kept between +2°C and +8°C.
Multi-dose vials of bOPV from which one or more doses of vaccine have been removed during an immunization session may be used in subsequent immunization sessions for up to a maximum of 4 weeks, provided that all of the following conditions are met (as described in the WHO policy statement: The use of opened multi dose vials in subsequent immunization sessions, WHO/V&B/00.09): The expiry date has not passed; The vaccines are stored under appropriate cold chain conditions; The vaccine vial septum has not been submerged in water; Aseptic technique has been used to withdraw all doses; The vaccine vial monitor (VVM), if attached, has not reached the discard point.
IMMUNIZATION SCHEDULE: Used for active immunization against poliomyelitis type 1 and 3. This vaccine can be used simultaneously with IPV. Infants should receive at least three doses of bOPV at minimum intervals of 4 weeks. WHO recommends the following schedule in endemic countries: Birth, 6, 10, 14 weeks. In non-endemic areas the first dose can be given from 6 weeks with the first dose of DTP.
